Vol. 4 (2024), Article ID 246169, 5 pages
Research Article
Impact of New Criteria for Gonadotoxic Risk Stratification on an Oncology Population in a Pediatric Hospital
Alejandra Dumenigo,1,2 Olivia Frias,2 Karen Burns,1,2 Julie Rios3
1College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA
2Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
3School of Medicine, University of Pittsburgh, Pittsburgh 15261, PA, USA
Received 9 January 2024; Revised 19 November 2024; Accepted 23 November 2024; Published 18 December 2024
Alejandra Dumenigo, Olivia Frias, Karen Burns, Julie Rios, Impact of New Criteria for Gonadotoxic Risk Stratification on an Oncology Population in a Pediatric Hospital, Journal of Fertility Preservation, 4 (2024), art246169. doi:10.32371/jfp/246169
Background. In 2020, new criteria were published for gonadotoxic risk stratification in pediatric patients receiving chemotherapy or radiation. The changes may impact fertility preservation (FP) counseling as some options for FP are experimental and only offered to those with high-risk stratification under current IRB protocols. Purpose. We describe the population affected by the change in criteria and how it impacted FP counseling. Methods. 241 charts within the Cincinnati Children’s Hospital Medical Center (CCHMC) fertility registry were reviewed for gonadotoxic treatment dosing at the time of FP consultation. Risk assessments were completed with the new criteria. Descriptive statistics were used to analyze data. Results. Of 241 patients, 5.4% (n = 13) had a change in risk stratification. Six patients would have been eligible for an experimental FP option by the new criteria. More of the eligible patients were male, had lymphoma, and had a risk change from intermediate to high risk (Table 1). Conclusion. Very few patients had a change in risk that affected FP options. Demographics and diagnosis were not homogenous but male patients and those with lymphoma were affected most.
risk stratification; gonadotoxic; CED; fertility preservation; gonadal insufficiency
Copyright © 2024 Alejandra Dumenigo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.