Table 8: DNA/methyl green colorimetric assay of the DNA-binding compounds.
DNA-active compound | DNA/methyl green (IC50, μg/mL) |
DOX | 31.27 ± 1.8 |
L | 29.18 ± 1.6 |
Pt(IV) | 82.27 ± 2.7 |
Cu(II) | 38.02 ± 1.9 |
Cd(II) | 45.35 ± 2.1 |
Ni(II) | 34.71 ± 1.8 |
IC50 values represent the concentration (mean ± SD, n = 3–5 separate determinations) required for a 50% decrease in the initial absorbance of the DNA/methyl green solution. |